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Published September 13, 2011 | Published + Supplemental Material
Journal Article Open

Architecture, constraints, and behavior


This paper aims to bridge progress in neuroscience involving sophisticated quantitative analysis of behavior, including the use of robust control, with other relevant conceptual and theoretical frameworks from systems engineering, systems biology, and mathematics. Familiar and accessible case studies are used to illustrate concepts of robustness, organization, and architecture (modularity and protocols) that are central to understanding complex networks. These essential organizational features are hidden during normal function of a system but are fundamental for understanding the nature, design, and function of complex biologic and technologic systems.

Additional Information

© 2011 National Academy of Sciences. Edited by Donald W. Pfaff, The Rockefeller University, New York, NY, and approved June 10, 2011 (received for review March 3, 2011). Published online before print July 25, 2011. We thank Mike Gazzaniga and Scott Grafton for helpful discussions and feedback. This work was partially supported by the National Science Foundation, the National Institutes of Health, the Air Force Office of Scientific Research, and the Institute of Collaborative Biotechnologies (Army Research Office W911NF-09-D-0001). This paper results from the Arthur M. Sackler Colloquium of the National Academy of Sciences, "Quantification of Behavior" held June 11–13, 2010, at the AAAS Building in Washington, DC. The complete program and audio files of most presentations are available on the NAS Web site at www.nasonline.org/quantification. Author contributions: J.C.D. and M.C. wrote the paper.

Attached Files

Published - Doyle2011p15862P_Natl_Acad_Sci_Usa.pdf

Supplemental Material - pnas.201103557SI.pdf


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