Manipulations of Neural Crest Cells or Their Migratory Pathways
- Creators
-
Bronner-Fraser, Marianne
- Other:
- Bronner-Fraser, Marianne
Abstract
This chapter discusses the manipulations of neural crest cells or their migratory pathways. The formation of the embryo involves intricate cell movements, cell proliferation, and differentiation. The neural crest has long served as a model for the study of these processes, because neural crest cells undergo extensive migrations and give rise to many diverse derivatives. Neural crest cells arise from the dorsal portion of the neural tube. Several unique properties of these cells make the neural crest an ideal system for studying cell migration and differentiation. First, these cells migrate extensively along characteristic pathways. Second, they give rise to diverse and numerous derivatives, ranging from pigment cells and cranial cartilage to adrenal chromaffin cells and the ganglia of the peripheral nervous system. In addition, their characteristic position of premigratory neural crest cells within the dorsal portion of the neural tube makes them accessible to surgical and molecular manipulations during the initial stages in their development.
Additional Information
© 1996 Academic Press, Inc. The author thanks Drs. Mary Dickinson, Scott Fraser, and Catherine Krull for helpful comments on the manuscript. Development of some of the methods described in this chapter comes from support by NIH Grants HD-25138, HD-15527, and DE-10066.Additional details
- Eprint ID
- 65267
- Resolver ID
- CaltechAUTHORS:20160310-141731239
- NIH
- HD-25138
- NIH
- HD-15527
- NIH
- DE-10066
- Created
-
2016-03-10Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field
- Series Name
- Methods in Cell Biology
- Series Volume or Issue Number
- 51