Endoscopic photoacoustic microscopy
We present a concept and system implementation for endoscopic photoacoustic microscopy that enables minimally invasive diagnosis of internal organs. The system incorporates an in-house made single element ultrasonic transducer for photoacoustic signal detection and an optical fiber for light delivery into a tubular probe with a mechanical scanning unit. The implemented probe size for the distal end is 4.2 mm in diameter and 48 mm in length. We evaluated the system's performance by imaging a carbon fiber in clear and turbid media. We also demonstrated its ability to image actual biological tissues and its endoscopic applicability, by imaging abdominal surfaces and a large intestinal tract of a rat ex vivo. This study shows the system's potential for in vivo optical biopsy of tissue abnormalities, such as tumors, developed in internal organs.
Additional Information© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by the National Institutes of Health grants R01 NS46214 (BRP), R01 EB000712, R01 EB008085, and U54 CA136398 (Network for Translational Research). L.W. has a financial interest in Endra, Inc., which, however, did not support this work. The authors are grateful to Namiki Precision, Inc. for supporting the micromotor and Hitachi Cable Manchester for supporting the micro-coaxial cable.
Published - 71770N.pdf