CaltechAUTHORS
Published January 2014 | Version public
Journal Article Metadata-only

A MicroRNA-mediated feedback loop controls vascular inflammatory signaling

Creators

Abstract

Activation of inflammatory signaling pathways in the endothelium contributes to vascular diseases, including sepsis and atherosclerosis. We find that a microRNA family (miR-146a and miR-J46b) is induced in endothelial cells upon exposure to pro-inflammatory cytokinc. Although transcription of the miR-146alb loci is rapidly induced, induction of mature miR-146a/b is delayed and sustained compared to the expression of leukocyte adhesion molecules, and in fact coincides with the down-regulation of inflammatory gene expression.

Additional Information

© 2013 Springer Science+Business Media Dordrecht.

Additional details

Identifiers

Eprint ID
43614
DOI
10.1007/s10456-013-9412-3
Resolver ID
CaltechAUTHORS:20140203-085822605

Related works

Describes
http://www.navbo.org/events/vb2013 (URL)

Dates

Created
2014-02-03
Created from EPrint's datestamp field
Updated
2021-11-10
Created from EPrint's last_modified field