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Published July 1986 | public
Journal Article Metadata-only

Competitive Adsorption of Divalent Cations and Cationic Polyelectrolytes on Phosphatidylglycerol Bilayer Membranes

Turek, Anne B.
Tirrell, David A. ORCID icon

Abstract

Adsorption of cationic polyelectrolytes on acidic phospholipid membranes can trigger profound changes in membrane organization. For example, treatment of a phosphate-buffered suspension of the acidic lipid dipalmitoylphosphatidylglycerol (DPPG, 1) with ionene-6,6 bromide (2) converts the normal L&dquo; DPPG bilayer to an unusual interdigitated arrangement (Scheme 1). We are currently exploring the relation between the structure of the adsorbed polyelectrolyte and the induction of acyl chain interdigitation in DPPG and related bilayers.

Additional Information

© 1986 Technomic Publishing Co. This work was supported by a grant from the 3M Co., St. Paul, MN. Support of our research by a Presidential Young Investigator Award of the National Science Foundation, and by a Research Fellowship of the Alfred P. Sloan Foundation, is also gratefully acknowledged. Part 12 in a series on "Interactions of Synthetic Polymers with Cell Membranes and Model Membrane Systems."

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Created:
August 19, 2023
Modified:
October 20, 2023