A Small-scale Procedure for Acid-catalyzed Ketal Formation
A modified procedure for dehydrative ketal protections is disclosed, which serves as an alternative to the classic Dean–Stark protocol. Studies show that this new procedure can outperform the Dean–Stark apparatus on small scales and thus serves as a complementary approach to effect dehydrative ketalizations. A detailed procedure for this apparatus is presented.
Additional Information© 2019 American Chemical Society. Received: June 10, 2019; Published: August 12, 2019. Caltech and the NSF (1800511) are thanked for funding. We are grateful to Dr. Alexander Sun (Caltech) for photographic assistance. The authors declare no competing financial interest.
Supplemental Material - jo9b01541_si_001.pdf