Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents
- Creators
- Matson, John B.
- Grubbs, Robert H.
- Others:
- Khosravi, E.
- Yagci, Yusuf
- Savelyev, Yuri
Abstract
Nanoparticles containing fluorine-18 were prepared from block copolymers made by ring-opening metathesis polymerization (ROMP). Using the fast initiating ruthenium metathesis catalyst (H_2IMes)(pyr)_2(Cl)_2RuCHPh, narrow polydispersity, amphiphilic block copolymers were prepared from a cinnamoyl-containing, hydrophobic norbornene monomer and a mesylate-terminated, PEG-containing hydrophilic norbornene monomer. Self-assembly into micelles and subsequent crosslinking of the micelle cores by light-activated dimerization of the cinnamoyl groups yielded stable nanoparticles. Incorporation of fluorine-18 was achieved by nucleophilic displacement of the mesylates with the radioactive fluoride ion with 31% incorporation of radioactivity. The resulting positron-emitting nanoparticles are to be used as in vivo molecular imaging agents in tumor imaging.
Additional Information
© 2009 Springer Science + Business Media B.V.Additional details
- Eprint ID
- 20748
- DOI
- 10.1007/978-90-481-3278-2_15
- Resolver ID
- CaltechAUTHORS:20101110-114544098
- Created
-
2010-11-18Created from EPrint's datestamp field
- Updated
-
2021-11-09Created from EPrint's last_modified field
- Series Name
- NATO Science for Peace and Security Series A-Chemistry and Biology