Toward functional ultrasound-modulated optical tomography: a phantom study
We present the feasibility of functional ultrasound-modulated optical tomography (UOT) in tissue phantoms with two optical wavelengths. By using intense acoustic bursts and a CCD camera-based speckle contrast detection technique, we observe variations of UOT signal at different optical absorptions. In addition, the results from Monte Carlo simulations highly correlate with the experimental outcomes. By irradiating the sample at two optical wavelengths, we quantitatively estimate the total concentration and the concentration ratio of double dyes in inclusions inside tissue phantoms. Therefore, UOT is potentially able to supply functional imaging of the total concentration and oxygen saturation of hemoglobin non-invasively in biological tissues.
Additional Information© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank Hao F. Zhang and Roger J. Zemp for fruitful scientific discussions. This research was supported by NIH Grant Nos. R33 CA 094267 and R01 CA106728.
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