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Published July 2020 | Published + Supplemental Material
Journal Article Open

Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo


Significance: Photoacoustic (PA) tomography has demonstrated versatile biomedical applications. However, an array-based PA computed tomography (PACT) system is complex and expensive, whereas a single-element detector-based scanning PA system is too slow to detect some fast biological dynamics in vivo. New PA imaging methods are sought after. Aim: To overcome these limitations, we developed photoacoustic topography through an ergodic relay (PATER), a novel high-speed imaging system with a single-element detector. Approach: PATER images widefield PA signals encoded by the acoustic ergodic relay with a single-laser shot. Results: We applied PATER in vivo to monitor changes in oxygen saturation in a mouse brain and also to demonstrate high-speed matching of vascular patterns for biometric authentication. Conclusions: PATER has achieved a high-speed temporal resolution over a large field of view. Our results suggest that PATER is a promising and economical alternative to PACT for fast imaging.

Additional Information

© 2020 The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 200043LR received Feb. 20, 2020; accepted for publication Jun. 26, 2020; published online Jul. 10, 2020. The authors appreciate the close reading of the manuscript by Professor James Ballard. This work was sponsored by the National Institutes of Health, Grant Nos. R01 CA186567 (NIH Director's Transformative Research Award), U01 NS090579 (NIH BRAIN Initiative), and U01 NS099717 (NIH BRAIN Initiative). Disclosures: L. V. W. and K. M. have financial interests in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which did not support this work.

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Published - 070501_1.pdf

Supplemental Material - JBO_25_7_070501_ds001.mp4

Supplemental Material - JBO_25_7_070501_ds002.mp4


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August 22, 2023
October 20, 2023