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Published May 2003 | Published
Journal Article Open

The N-end rule and regulation of apoptosis


The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabilizing N-terminal residues. This pathway is known to control the import of peptides, chromosome stability and cardiovascular development. A new report identifies yet another function of the N-end rule pathway: the regulation of apoptosis through degradation of Drosophila melanogaster DIAP1.

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© 2003 Nature Publishing Group.

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