Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system
- Creators
- Montagne, Axel
-
Nikolakopoulou, Angeliki M.
- Zhao, Zhen
- Sagare, Abhay P.
- Si, Gabriel
- Lazic, Divna
-
Barnes, Samuel R.1
- Daianu, Madelaine
- Ramanathan, Anita
- Go, Ariel
- Lawson, Erica J.
- Wang, Yaoming
- Mack, William J.
- Thompson, Paul M.
- Schneider, Julie A.
- Varkey, Jobin
- Langen, Ralf
- Mullins, Eric
-
Jacobs, Russell E.1
-
Zlokovic, Berislav V.
-
1.
California Institute of Technology
Abstract
Diffuse white-matter disease associated with small-vessel disease and dementia is prevalent in the elderly. The biological mechanisms, however, remain elusive. Using pericyte-deficient mice, magnetic resonance imaging, viral-based tract-tracing, and behavior and tissue analysis, we found that pericyte degeneration disrupted white-matter microcirculation, resulting in an accumulation of toxic blood-derived fibrin(ogen) deposits and blood-flow reductions, which triggered a loss of myelin, axons and oligodendrocytes. This disrupted brain circuits, leading to white-matter functional deficits before neuronal loss occurs. Fibrinogen and fibrin fibrils initiated autophagy-dependent cell death in oligodendrocyte and pericyte cultures, whereas pharmacological and genetic manipulations of systemic fibrinogen levels in pericyte-deficient, but not control mice, influenced the degree of white-matter fibrin(ogen) deposition, pericyte degeneration, vascular pathology and white-matter changes. Thus, our data indicate that pericytes control white-matter structure and function, which has implications for the pathogenesis and treatment of human white-matter disease associated with small-vessel disease.
Errata
Retraction to: Nature Medicine https://doi.org/10.1038/nm.4482, published online 5 February 2018.
The authors have retracted this article. After publication, concerns were raised regarding the images presented in the figures and supplementary materials. Specifically:
- 1.
Fig. 4n S1Cx +/+ and F7/F7 images appear to overlap with each other, as well as with Fig. 7f Cortex APPsw/0,PDGFRb+/+ and Fig. S3b Cortex PDGFRb+/+ in ref. 1;
- 2.
Fig. S7a CC +/+ and F7/F7 images appear to overlap;
- 3.
Fig. S11d F7/F7 and Fig. S12h F7/F7 CA1 images appear highly similar (with rotation);
- 4.
Fig. S13a Vehicle and Fibrinogen images appear to overlap.
The authors have determined that these issues occurred due to incorrect selection of images during manuscript preparation. The authors are reviewing their data and may submit a new manuscript for peer review in due course.
Axel Montagne, Angeliki M. Nikolakopoulou, Zhen Zhao, Abhay P. Sagare, Divna Lazic, Samuel R. Barnes, Anita Ramanathan, Yaoming Wang, William J. Mack, Julie A. Schneider, Jobin Varkey, Ralf Langen, Eric Mullins, Russell E. Jacobs and Berislav V. Zlokovic agree with this retraction.
Gabriel Si, Madelaine Daianu, Ariel Go, Erica J. Lawson and Paul M. Thompson have not responded to any correspondence from the editors or could not be reached by email.
Additional details
- Alternative title
- Pericyte degeneration causes white matter dysfunction in the mouse CNS
- NIH
- NS100459
- NIH
- AG039452
- NIH
- NS034467
- NIH
- AG023084
- Foundation Leducq
- 16 CVD 05
- NIH
- ES024936
- Available
-
2024-04-05Published
- Publication Status
- Published