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Published April 15, 2013 | public
Journal Article

Development of functional assays for p97/VCP inhibition


p97 (also called VCP in metazoans and CDC48 in yeast) is a highly conserved, ubiquitously expressed, and essential AAA ATPase. p97 plays a key role in endoplasmic reticulum-associated degradation of misfolded secretory and membrane proteins as well as ubiquitin-dependent turnover of a subset of cytoplasmic substrates of the ubiquitin-proteasome system.

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© 2013 American Association for Cancer Research. Funded by NExT Chemical Biology Consortium, NCI Contract No. HHSN261200800001E.

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