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Published April 1, 2018 | Published + Supplemental Material
Journal Article Open

Neural phase locking predicts BOLD response in human auditory cortex


Natural environments elicit both phase-locked and non-phase-locked neural responses to the stimulus in the brain. The interpretation of the BOLD signal to date has been based on an association of the non-phase-locked power of high-frequency local field potentials (LFPs), or the related spiking activity in single neurons or groups of neurons. Previous studies have not examined the prediction of the BOLD signal by phase-locked responses. We examined the relationship between the BOLD response and LFPs in the same nine human subjects from multiple corresponding points in the auditory cortex, using amplitude modulated pure tone stimuli of a duration to allow an analysis of phase locking of the sustained time period without contamination from the onset response. The results demonstrate that both phase locking at the modulation frequency and its harmonics, and the oscillatory power in gamma/high-gamma bands are required to predict the BOLD response. Biophysical models of BOLD signal generation in auditory cortex therefore require revision and the incorporation of both phase locking to rhythmic sensory stimuli and power changes in the ensemble neural activity.

Additional Information

© 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Open Access funded by National Institutes of Health. Received 18 August 2017, Revised 22 November 2017, Accepted 16 December 2017, Available online 22 December 2017. This work was supported by NIDCD (DC04290) and the Hoover fund. We thank all the members of Human Brain Research Laboratory (HRBL) at The University of Iowa, especially Haiming Chen, Matt Sutterer and Ariane Rhone for their help with conducting experiments. We thank Karl J. Friston and Nikos K. Logothetis for helpful discussion about the findings. We would like to thank the patients who contributed their time for the experiments. The authors declare no competing financial interests.

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Published - 1-s2.0-S1053811917310753-main.pdf

Supplemental Material - mmc1.pdf


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