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Published August 14, 2012 | Supplemental Material + Published
Journal Article Open

A magnetic cell-based sensor


Cell-based sensing represents a new paradigm for performing direct and accurate detection of cell- or tissue-specific responses by incorporating living cells or tissues as an integral part of a sensor. Here we report a new magnetic cell-based sensing platform by combining magnetic sensors implemented in the complementary metal-oxide-semiconductor (CMOS) integrated microelectronics process with cardiac progenitor cells that are differentiated directly on-chip. We show that the pulsatile movements of on-chip cardiac progenitor cells can be monitored in a real-time manner. Our work provides a new low-cost approach to enable high-throughput screening systems as used in drug development and hand-held devices for point-of-care (PoC) biomedical diagnostic applications.

Additional Information

© 2012 Royal Society of Chemistry. Received 23 Apr 2012, Accepted 13 Aug 2012. First published on the web 14 Aug 2012. H. W. was supported by a California Institute of Technology Innovation Initiative (CI2) Research Grant. A.M. was supported by a National Science and Engineering Research Council of Canada (NSERC) Scholarship, a post-graduate scholarship by Caltech Donna and Benjamin M. Rosen Center for Bioengineering and the NSF Center for the Science and Engineering of Materials at Caltech (NSF DMR 0520565). The authors would like to acknowledge Dr Shouhei Kousai for his support on the CMOS magnetic sensor chip development; Constantine Sideris for his help on developing the FPGA Verilog programs; Alex Pai for his support on building the sensor modules; and United Microelectronics Corporation (UMC) for providing CMOS sensor chip foundry service.

Attached Files

Published - c2lc40392g.pdf

Supplemental Material - c2lc40392g_supp.pdf


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September 14, 2023
September 14, 2023