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Published 1990 | Published
Journal Article Open

Contributions of Cell-extrinsic and Cell-intrinsic Factors to the Differentiation of a Neural-crest-derived Neuroendocrine Progenitor Cell


A central question in developmental neurobiology concerns the mechanisms that generate cellular diversity in the vertebrate nervous system. Cell lineage analyses have established that many progenitor cells in the developing nervous system are multipotent (Turner and Cepko 1987; Holt et al. 1988; Wetts and Fraser 1988). However, the mechanisms that control the differentiation of such progenitor cells are poorly understood.

Additional Information

© 1990 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/) Some of the work described in this paper was supported by National Institutes of Health (NIH) grant NS-23476, Searle Scholars and National Science Foundation Presidential Young Awards to D.J.A., and a U.S.-Israeli Binational Science Foundation grant to R.S. We thank LiChing Lo and Steven Padilla for technical assistance and Helen Walsh for preparation of the manuscript. We are also grateful to our colleagues Paul Patterson and Barbara Wold for frequent helpful discussions. S.J.B. was supported by a Damon Runyon-Walter Winchell postdoctoral fellowship and D.J.V. and C.W.W. by NIH fellowships.

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