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Published January 2015 | Published
Journal Article Open

In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography


Using internal illumination with an optical fiber in the oral cavity, we demonstrate, for the first time, photoacoustic computed tomography (PACT) of the deep brain of rats in vivo. The experiment was performed on a full-ring-array PACT system, with the capability of providing high-speed cross-sectional imaging of the brain. Compared with external illumination through the cranial skull, internal illumination delivers more light to the base of the brain. Consequently, in vivo photoacoustic images clearly reveal deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.

Additional Information

© 2015 SPIE. Paper 140725R received Nov. 3, 2014; accepted for publication Jan. 6, 2015; published online Jan. 22, 2015. The authors would like to thank Prof. James Ballard and Dr. Junjie Yao for close reading of the manuscript. This work was supported in part by National Institutes of Health Grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), R01 EB016963, and R01 EB010049. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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August 22, 2023
October 20, 2023