Social and Communication Development in Infants with Isolated Agenesis of the Corpus Callosum
Abstract
Objective
To evaluate the development of social behavior, communication, emotion regulation, and repetitive behaviors in infants with congenital malformation of the corpus callosum, specifically those with isolated Agenesis of the Corpus Callosum (ACC) in comparison to typically developing infants.
Study Design
This case-control longitudinal observation study examined parent report of social behavior, social-communication, emotion regulation, and repetitive behavior development in community ascertained infants (n = 156) and infants with isolated ACC (n = 57) between 12 and 24 months of age.
Results
Infants with isolated ACC produced fewer words at 12- (p = 0.003) 18- (p < 0.001), and 24-months of age (p = 0.003), and fewer gestures at 12- (p < 0.001), 18- (p < 0.001), and 24-months of age (p < 0.001). In addition, the ACC group demonstrated delays in reciprocal social behavior at 18-months (p = 0.01) and social competence at 12- (p < 0.001) and 18-months (p = 0.01). No concerns were noted in emotion regulation or restricted and repetitive behavior and social behavior appears to normalize at 24 months.
Conclusions
Existing data suggests heterogeneity in developmental outcomes among individuals with isolated ACC. The current findings fill a gap in knowledge about development in the second year of life. Surveillance of social and communication ability in infants with ACC may be warranted. The role of the corpus callosum in facilitating rapid interhemispheric information processing impacts skills beyond the motor system. More work is needed to identify intervention targets for infants and toddlers with ACC.
Copyright and License
© 2024 The Author(s). Published by Elsevier Under a Creative Commons license.
Acknowledgement
Drs. Paul and Elison had full access to the data in this study and take full responsibility for the integrity of the data and the accuracy of the results. We are indebted to the families who graciously provided their time for this research.
Contributions
Lynn K. Paul: Writing – review & editing, Visualization, Supervision, Project administration, Methodology, Investigation, Funding acquisition, Conceptualization. Jasmin Turner: Writing – review & editing, Visualization, Resources, Investigation, Formal analysis. Sooyeon Sung: Writing – review & editing, Visualization, Resources, Investigation, Formal analysis. Jed T. Elison: Writing – original draft, Supervision, Resources, Project administration, Methodology, Investigation, Funding acquisition, Data curation, Conceptualization.
Data Availability
Supplementary Material / Appendix: Supplementary material or an appendix is available at The Journal of Pediatrics: X online.
Files
| Name | Size | Download all |
|---|---|---|
|
md5:6a50fb817fc7f41858602a258c07e1e2
|
690.0 kB | Download |
|
md5:fb8827394f1e1658c3e18595ad5aa03c
|
1.9 MB | Preview Download |