Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published September 2004 | Published
Book Section - Chapter Open

High-resolution ultrasound-aided biophotonic imaging


Optical contrast is sensitive to functional parameters, including the oxygen saturation and total concentration of hemoglobin, in biological tissues. However, due to the overwhelming scattering encountered by light in tissues, traditional optical modalities cannot provide satisfactory spatial resolution beyond the ballistic (a few hundred microns) and quasiballistic (1-2 mm) regimes. Photoacoustic tomography is based on the high optical contrast yet utilizing the high ultrasonic resolution. Our work in this emerging area of research will be summarized in this invited talk. In this technology, a diffraction-based inverse-source problem is solved in the image reconstruction, for which we developed the rigorous reconstruction theory. We implemented a prototype and accomplished noninvasive transdermal and transcranial functional imaging of small-animal brains in vivo. Change in the cerebral blood oxygenation of a rat, as a result of the alternation from hyperoxia to hypoxia, was imaged successfully.

Additional Information

© 2004 IEEE. This project was sponsored in part by the U.S. Army Medical Research and Materiel Command Grant No. DAMD17–00-1–0455, the National Institutes of Health Grants No. R01 EB000712 and No. R01 NS46214, and Texas Higher Education Coordinating Board Grant No. ARP 000512–0063-2001.

Attached Files

Published - 01404482.pdf


Files (408.7 kB)
Name Size Download all
408.7 kB Preview Download

Additional details

August 19, 2023
October 20, 2023