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Published July 31, 1987 | public
Journal Article

Molecular Characterization of Shaker, a Drosophila Gene That Encodes a Potassium Channel


The Drosophila Shaker (Sh) gene appears to encode a type of voltage-sensitive potassium (K+) channel called the A channel. We have isolated Sh as part of a 350 kb chromosomal walk. The region around Sh contains four identified transcription units. We find that Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron. Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel.

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© 1987 Cell Press. Received June 18, 1987. A. L. and L. I. contributed equally to the work presented here. We thank D. Ballinger, U. Banerjee, M. Gautam, J. Pollock, M. Ramaswami, J. Tseng-Crank, and K. VijayRaghavan for comments. This research was supported by the Pfeiffer Research Foundation and USPHS grant NS21327-01 to M. T. L. I. was supported by a Muscular Dystrophy Association Fellowship and the E. S. Gosney Fund. A. K. was supported by NRSA training grant GM07616. M. T. is a McKnight Foundation Scholar and a Sloan Foundation Fellow. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC. Section 1734 solely to indicate this fact.

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