Neural crest lineage analysis: from past to future trajectory
- Creators
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Tang, Weiyi
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Bronner, Marianne E.
Abstract
Since its discovery 150 years ago, the neural crest has intrigued investigators owing to its remarkable developmental potential and extensive migratory ability. Cell lineage analysis has been an essential tool for exploring neural crest cell fate and migration routes. By marking progenitor cells, one can observe their subsequent locations and the cell types into which they differentiate. Here, we review major discoveries in neural crest lineage tracing from a historical perspective. We discuss how advancing technologies have refined lineage-tracing studies, and how clonal analysis can be applied to questions regarding multipotency. We also highlight how effective progenitor cell tracing, when combined with recently developed molecular and imaging tools, such as single-cell transcriptomics, single-molecule fluorescence in situ hybridization and high-resolution imaging, can extend the scope of neural crest lineage studies beyond development to regeneration and cancer initiation.
Additional Information
© 2020 Published by The Company of Biologists Ltd. We thank Dr Vicky Prince for helpful suggestions on the manuscript. The authors declare no competing or financial interests. The authors' research was funded by the National Institutes of Health (DE027568, R35NS111564 and NIHRO1HL14058 to M.E.B.). Deposited in PMC for release after 12 months.Attached Files
Published - dev193193.full.pdf
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Additional details
- PMCID
- PMC7595686
- Eprint ID
- 106289
- Resolver ID
- CaltechAUTHORS:20201027-081451617
- NIH
- DE027568
- NIH
- R35NS111564
- NIH
- RO1HL14058
- Created
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2020-10-27Created from EPrint's datestamp field
- Updated
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2022-02-08Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering