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Published May 2008 | Accepted Version
Journal Article Open

Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body


Receptor tyrosine phosphatases (RPTPs) are required for axon guidance during embryonic development in Drosophila. Here we examine the roles of four RPTPs during development of the larval mushroom body (MB). MB neurons extend axons into parallel tracts known as the peduncle and lobes. The temporal order of neuronal birth is reflected in the organization of axons within these tracts. Axons of the youngest neurons, known as core fibers, extend within a single bundle at the center, while those of older neurons fill the outer layers. RPTPs are selectively expressed on the core fibers of the MB. Ptp10D and Ptp69D regulate segregation of the young axons into a single core bundle. Ptp69D signaling is required for axonal extension beyond the peduncle. Lar and Ptp69D are necessary for the axonal branching decisions that create the lobes. Avoidance of the brain midline by extending medial lobe axons involves signaling through Lar.

Additional Information

© 2008 Elsevier Inc. Received 17 July 2007; revised 18 January 2008; accepted 25 January 2008. Available online 13 February 2008. We thank Dr. Emiko Suzuki and members of the Zinn and Suzuki groups for helpful discussions, and the Caltech Biological Imaging Facility for use of equipment. This work was supported by an NIH RO1 grant, NS28182, to K. Zinn, and by a Postdoctoral Fellowship for Research Abroad of the Japan Society for the Promotion of Science for Young Scientists, a grant from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a grant from the Naito Foundation to M. Kurusu.

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