Published January 25, 2010 | Version Supplemental Material + Accepted Version
Journal Article Open

Ruthenium Olefin Metathesis Catalysts Bearing Carbohydrate-Based N-Heterocyclic Carbenes

Abstract

Ru-based olefin metathesis catalysts containing carbohydrate-derived NHCs from glucose and galactose were synthesized and characterized by NMR spectroscopy. 2D-NMR spectroscopy revealed the presence of Ru−C (benzylidene) rotamers at room temperature, and the rate of rotation was measured using magnetization transfer and VT-NMR spectroscopy. The catalysts were found to be effective at ring-opening metathesis polymerization (ROMP), ring-closing metathesis (RCM), cross-metathesis (CM), and asymmetric ring-opening cross-metathesis (AROCM) and showed surprising selectivity in both CM and AROCM.

Additional Information

© 2010 American Chemical Society. Received October 5, 2009; publication Date (Web): December 18, 2009. We thank Dr. David VanderVelde and Prof. Dan O'Leary for assisting with the 2D-NMR characterization and line shape analysis, respectively, and thank both for helpful discussions. We also thank Prof. Brian Stoltz for the use of his groups' Chiral HPLC. We gratefully acknowledge the financial support of the NSF and NIH (Grant No. 5R01 GM31332), and B.K.K. thanks the NDSEG for a graduate fellowship. Finally, we thank Materia, Inc., for a generous donation of ruthenium complex 1.

Attached Files

Accepted Version - nihms166527.pdf

Supplemental Material - om900864r_si_001.pdf

Files

nihms166527.pdf

Files (2.4 MB)

Name Size Download all
md5:208a4d841ad55e520ddda95a67047252
815.6 kB Preview Download
md5:22c248fa307377c8666e94fa85145b2b
1.6 MB Preview Download

Additional details

Identifiers

PMCID
PMC3097126
Eprint ID
17429
DOI
10.1021/om900864r
Resolver ID
CaltechAUTHORS:20100209-094025316

Related works

Describes
10.1021/om900864r (DOI)

Funding

NSF
NIH
5R01 GM31332
National Defense Science and Engineering Graduate (NDSEG) Fellowship

Dates

Created
2010-02-10
Created from EPrint's datestamp field
Updated
2021-11-08
Created from EPrint's last_modified field