Multimodal single-neuron, intracranial EEG, and fMRI brain responses during movie watching in human patients

Copyright and License

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Acknowledgement

We would like to express our deepest gratitude to the patients who volunteered to participate in this study. We thank the clinical team at Cedars-Sinai Medical Center for patient management, Michael Kyzar for advice on NWB usage, and Nand Chandravadia, and April Carlson for assistance with data processing. We thank Rhodri Cusack for sharing the edited version of the Hitchcock movie with us. This study was supported by the NIMH Caltech Conte Center (P50MH094258 to R.A. and U.R.), the BRAIN initiative through the National Institute of Neurological Disorders and Stroke (U01NS117839 to U.R.), the Simons Collaboration on the Global Brain (542941 to R.A. and U.R.), and the National Science Foundation (BCS-2219800).

Contributions

J.D. and U.R. conceived the original study and designed the experiment. J.D., U.R. and J.M.T. performed experiments. U.K., J.D., K.J.M.L., J.M.T. and D.A.K. organized the data. U.K. analyzed the data. A.N.M. performed surgery and supervised clinical care. J.M.C. and C.M.R. enrolled patients, provided clinical care, and supervised MRI scanning. U.R. and R.A. provided supervision and acquired funding. U.K., K.J.M.L., J.M.T., R.A. and U.R. wrote the manuscript. All the authors reviewed and approved the manuscript for submission.

Code Availability

All code is available in the GitHub repository (https://github.com/rutishauserlab/bmovie-release-NWB-BIDS). The python code includes scripts to read and plot the data from the NWB files and perform the analyses presented in this data descriptor. The code relies heavily on open-source Python packages such as numpy⁶¹, scipy⁶², pynwb¹⁸, mne-python⁶³, nilearn⁴⁸, and pycortex⁶⁴. The movie annotation files are also provided in the GitHub repository under ‘assets/annotations’ folder. The scripts related to the estimation of tSNR and ISC were adapted from the code provided in the GitHub repository associated with the budapest-fmri-data study^49,50 (see: https://github.com/mvdoc/budapest-fmri-data).

Conflict of Interest