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Published September 1950 | Published
Journal Article Open

Incorporation in vitro of labeled amino acids into bone marrow cell proteins


Nearly all experiments on the incorporation of labeled amino acids into tissue proteins in vitro have been done on tissues whose cell structure has been partially or completely disintegrated, e.g. tissue slices, segments, or homogenates. Since cell destruction reduces or abolishes the uptake of labeled amino acids (1), it seemed worth while to carry out studies on intact cells in vitro. Bone marrow cells were found to be suitable for this purpose. The labeled amino acids used were glycine-1-C14, L-leucine-1-C14, L-lysine-1-C14, and L-lysine-6-C14.

Additional Information

© 1950 American Society of Biological Chemists. Received for publication, February 25, 1950. This work was carried out under the joint sponsorship of the United States Atomic Energy Commission and the Office of Naval Research. The C14 used was supplied by the Carbide and Carbon Chemicals Corp., Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.

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