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Published October 2003 | public
Journal Article

Electrochemical DNA sensors


Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical sensors exploit a range of different chemistries, but all take advantage of nanoscale interactions between the target in solution, the recognition layer and a solid electrode surface. Numerous approaches to electrochemical detection have been developed, including direct electrochemistry of DNA, electrochemistry at polymer-modified electrodes, electrochemistry of DNA-specific redox reporters, electrochemical amplifications with nanoparticles, and electrochemical devices based on DNA-mediated charge transport chemistry.

Additional Information

© 2003 Nature Publishing Group. Published online 30 September 2003. We are grateful to the National Institutes of Health for their financial support of our research.

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August 19, 2023
October 20, 2023