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Published October 19, 2001 | Supplemental Material
Journal Article Open

Formation of Macrocycles via Ring-Closing Olefin Metathesis


The enhanced metathesis activity of 1,3-dimesityl-4,5-dihydroimidazole-2-ylidene ruthenium carbene catalyst 3 significantly increases the feasibility of synthesizing macrocyclic compounds. Catalyst 3 exhibits sufficient activity in RCM to dimerize α,β-unsaturated ester substrates and afford the corresponding head-to-tail (E,E)-dimeric (and trimeric) macrocycles. The dimerization appears to be under thermodynamic control with the product mixture dependent not only on the electronic and steric nature of the substrate but also on concentration.

Additional Information

© 2001 American Chemical Society. Received June 18, 2001; Publication Date (Web): September 15, 2001. Support has been generously provided by the National Institutes of Health. John P. Morgan, Christopher W. Bielawski, Arnab K. Chatterjee, and Tae-Lim Choi are also acknowledged for helpful discussions.

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