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Published August 25, 2008 | Supplemental Material + Accepted Version
Journal Article Open

Catalytic Enantioselective Alkylation of Substituted Dioxanone Enol Ethers: Ready Access to C(α)-Tetrasubstituted Hydroxyketones, Acids, and Esters


Adaptive Alkylation: Palladium-catalyzed asymmetric alkylation enables access to fully substituted enantioenriched oxygenated stereocenters, which can be transformed easily to α-hydroxyketones, esters, and acids, providing a catalytic, enantioselective synthesis for natural products.

Additional Information

© 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: March 25, 2008; Revised: May 1, 2008; Published online: July 24, 2008. The authors thank the Takeda Pharmaceutical Company Limited of Japan (postdoctoral fellowship to M.S.), the California Tobacco-Related Disease Research Program of the University of California, Grant Number 14DT-0004 (predoctoral fellowship to J.L.R.), the NIH-NIGMS (R01 GM 080269-01), and Caltech for financial support, Materia, Inc. for their generous donation of catalyst 9 used in these studies, and Dr. S. Virgil, A. Silberstein, and Y. Segawa for experimental assistance.

Attached Files

Accepted Version - nihms60669.pdf

Supplemental Material - anie_200801424_sm_miscellaneous_information.pdf


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August 22, 2023
October 24, 2023