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Published March 21, 2024 | Version Published
Journal Article Metadata-only

How transcription factor binding controls transcriptional bursting dynamics: A single-molecule view

Creators

  • 1. ROR icon California Institute of Technology

Abstract

In this issue, Pomp et al.1 simultaneously tracked transcriptional bursts of yeast gene GAL10 and transient binding of transcription factor Gal4 at the gene using novel methods. Dynamic exchange and infrequent long binding of Gal4 together enable prolonged transcriptional bursts of GAL10.

    Copyright and License

    © 2024 Elsevier.

    Acknowledgement

    The authors are supported by the National Science Foundation Graduate Research Fellowship Program under grant no. DGE-1745301 (S.Y.), the Pew-Stewart Scholar for Cancer Research Award (S.C.), the Searle Scholar Award (S.C.), the Shurl and Kay Curci Foundation Research Grant (S.C.), the Merkin Innovation Seed Grant (S.C.), the Mallinckrodt Research Grant (S.C.), and the Margaret E. Early Medical Research Trust 2024 Grant (S.C.). S.C. is also supported by the NIH/National Cancer Institute (NCI) under award number P30CA016042.

    Conflict of Interest

    The authors declare no conflicts of interest.

     

    Additional details

    Funding

    National Science Foundation
    NSF Graduate Research Fellowship DGE-1745301
    Pew Charitable Trusts
    Chicago Community Trust
    Shurl and Kay Curci Foundation
    California Institute of Technology
    Richard N. Merkin Institute for Translational Medicine
    Edward Mallinckrodt Jr. Foundation
    National Institutes of Health
    P30CA016042

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    Richard N. Merkin Institute for Translational Research