How transcription factor binding controls transcriptional bursting dynamics: A single-molecule view

Creators: Chong, Shasha¹; Yoshida, Shawn

1. California Institute of Technology

Abstract

In this issue, Pomp et al.¹ simultaneously tracked transcriptional bursts of yeast gene GAL10 and transient binding of transcription factor Gal4 at the gene using novel methods. Dynamic exchange and infrequent long binding of Gal4 together enable prolonged transcriptional bursts of GAL10.

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Acknowledgement

The authors are supported by the National Science Foundation Graduate Research Fellowship Program under grant no. DGE-1745301 (S.Y.), the Pew-Stewart Scholar for Cancer Research Award (S.C.), the Searle Scholar Award (S.C.), the Shurl and Kay Curci Foundation Research Grant (S.C.), the Merkin Innovation Seed Grant (S.C.), the Mallinckrodt Research Grant (S.C.), and the Margaret E. Early Medical Research Trust 2024 Grant (S.C.). S.C. is also supported by the NIH/National Cancer Institute (NCI) under award number P30CA016042.

Conflict of Interest

The authors declare no conflicts of interest.

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Resource type: Journal Article
Publisher: Cell Press
Published in: Molecular Cell, 84(6), 997-999, ISSN: 1097-2765.
Languages: English

Created:: March 27, 2024
Modified:: March 27, 2024