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Published April 14, 2008 | Published
Journal Article Open

Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser


We build a photoacoustic imaging system using an intensity-modulated continuous-wave laser source, which is an inexpensive, compact, and durable 120-mW laser diode. The goal is to significantly reduce the costs and sizes of photoacoustic imaging systems. By using a bowl-shaped piezoelectric transducer, whose numerical aperture is 0.85 and resonance frequency is 2.45 MHz, we image biological tissues with a lateral resolution of 0.45 mm, an axial resolution of 1 mm, and an SNR as high as 43 dB.

Additional Information

© 2008 SPIE. Paper 07131RR received Apr. 6, 2007; revised manuscript received Oct. 29, 2007; accepted for publication Nov. 7, 2007; published online Apr. 14, 2008. This paper is a revision of a paper presented at the SPIE Conference on Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-Optics, Jan. 2007, San Jose, California. The paper presented there appears (unrefereed) in SPIE Proceedings Vol. 6437. We thank Z. Huang for experimental assistance. This project is sponsored by National Institutes of Health Grants R01 EB000712 and R01 NS46214.

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