Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published April 14, 2021 | Accepted Version
Journal Article Open

Enantioselective Formation of Quaternary Centers by Allylic Alkylation with First-Row Transition-Metal Catalysts


Asymmetric allylic alkylation mediated by transition metals provides an efficient strategy to form quaternary stereogenic centers. While this transformation is dominated by the use of second- and third-row transition metals (e.g., Pd, Rh, and Ir), recent developments have revealed the potential of first-row transition metals, which provide not only a less expensive and potentially equally efficient alternative but also new mechanistic possibilities. This review summarizes examples for the assembly of quaternary stereocenters using prochiral allylic substrates and hard, achiral nucleophiles in the presence of copper complexes and highlights the complementary approaches with soft, prochiral nucleophiles catalyzed by chiral cobalt and nickel complexes.

Additional Information

© 2021 American Chemical Society. Received: October 13, 2020; Published: February 11, 2021. We thank NIH-NIGMS (R01GM080269) and Caltech for financial support. L.S. gratefully acknowledges the Alexander von Humboldt Foundation for a postdoctoral fellowship (2020). Author Contributions: The manuscript was written through contributions of all authors. The authors declare no competing financial interest.

Attached Files

Accepted Version - nihms-1746780.pdf


Files (5.8 MB)
Name Size Download all
5.8 MB Preview Download

Additional details

August 20, 2023
October 23, 2023