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Published October 1995 | public
Journal Article

Silencing is golden: negative regulation in the control of neuronal gene transcription


Recent work has identified negative-acting DNA regulatory elements that function to prevent the expression of neuronal genes in non-neuronal cell types or in inappropriate neuronal subtypes. In some cases, the protein factors that interact with these silencer elements have been isolated and characterized. For example, the recently cloned silencer-binding factor NRSF/REST is a novel zinc-finger protein that interacts with silencer elements in a number of neuron-specific genes. These data suggest that negative regulation plays a major role in determining the diverse patterns of gene expression within the nervous system.

Additional Information

© 1995 Current Biology Ltd. Available online 11 February 2002. Portions of the work cited from the authors laboratory was supported by NIH grant NS23476. D.J. Anderson is an Associate Investigator of the Howard Hughes Medical Institute.

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August 20, 2023
October 20, 2023