Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 2016 | Accepted Version
Journal Article Open

Single-cell analysis tools for drug discovery and development


The genetic, functional or compositional heterogeneity of healthy and diseased tissues presents major challenges in drug discovery and development. Such heterogeneity hinders the design of accurate disease models and can confound the interpretation of biomarker levels and of patient responses to specific therapies. The complex nature of virtually all tissues has motivated the development of tools for single-cell genomic, transcriptomic and multiplex proteomic analyses. Here, we review these tools and assess their advantages and limitations. Emerging applications of single cell analysis tools in drug discovery and development, particularly in the field of oncology, are discussed.

Additional Information

© 2015 Macmillan Publishers Limited. Published online 16 December 2015. The authors acknowledge the following funding agencies and grants for support of some of the work described in this Review: The National Cancer Institute (5R01CA170689 to J.R.H. as the principal investigator (PI) and A.R. as the co-PI, and 5U54 CA119347 to J.R.H. as the PI); Stand up to Cancer Foundation (to A.R. and J.R.H.); the Cancer Research Institute (to A.R. and J.R.H.); The Ben and Catherine Ivy Foundation (to P.S.M. and J.R.H.); and the Jean Perkins Foundation (to J.R.H. as the PI). Competing interests statement: J.R.H. and A.R. are on the Scientific Advisory Board of Isoplexis, which is seeking to commercialize certain aspects of the single-cell barcode chip technology.

Attached Files

Accepted Version - nihms787676.pdf


Files (797.4 kB)
Name Size Download all
797.4 kB Preview Download

Additional details

August 22, 2023
October 25, 2023