Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published February 6, 1998 | Supplemental Material
Journal Article Open

A Highly Efficient and Practical Synthesis of Chromene Derivatives Using Ring-Closing Olefin Metathesis


Chromenes (2H-1-benzopyran derivatives) have been widely employed as important intermediates in the synthesis of many natural products and medicinal agents. There has been recent interest in the use of these common structural elements for a new family of potassium-channel activating drugs. They also serve as the framework of a range of tannins, which are becoming increasingly important because of their health-promoting effects found in teas, vegetables, fruits, fruit juices, and red wines. Despite the several existing methods for the synthesis of chromene derivatives, there still is demand for general strategies which can efficiently provide variously substituted chromene systems. In this note, we report a practical and highly efficient procedure for preparing diverse chromene derivatives using ring-closing metathesis (RCM), a methodology emerging as a new tool in synthetic organic chemistry

Additional Information

© 1998 American Chemical Society. Received July 3, 1997. This research was supported by National Institute of Health.

Attached Files

Supplemental Material - jo864.pdf


Files (326.6 kB)
Name Size Download all
326.6 kB Preview Download

Additional details

August 19, 2023
October 18, 2023