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Published August 29, 2013 | Published
Journal Article Open

Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research


Single-cell functional proteomics assays can connect genomic information to biological function through quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years and are providing approaches for directly elucidating phosphoprotein signaling networks in cancer cells or for capturing high-resolution snapshots of immune system function in patients with various disease conditions. We discuss advances in single-cell proteomics platforms, with an emphasis on microchip methods. These methods can provide a direct correlation of morphological, functional and molecular signatures at the single-cell level. We also provide examples of how those platforms are being applied to both fundamental biology and clinical studies, focusing on immune-system monitoring and phosphoprotein signaling networks in cancer.

Additional Information

© 2013 BioMed Central Ltd. Published: 29 August 2013. Some of the work reviewed here was supported by the National Cancer Institute (5U54 CA119347 and R01 CA170689-01 to JRH) and the National Institutes of Health (NIH 1 U01 CA164252-01 to RF and U54 CA143798 to RF).

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