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Published October 2019 | public
Journal Article

Modularity: Adding New Dimensions to Total Synthesis


As the field of synthetic chemistry seeks to tackle new frontiers, total synthesis is primed to address significant medical challenges such as the rise of antibiotic resistance and cancer. One emerging frontier focuses on increasingly concerted efforts to utilize modular total synthesis as a strategy to generate analogs of natural product targets for biological studies, with the ultimate goal of new therapeutic development. This new frontier is enabled by a confluence of human ingenuity in synthetic design, newly developed reactions that facilitate advances in total synthesis strategies, and emerging technologies. In this review, we highlight the evolving trend of modular total synthesis, including new reactions and automated technologies. This trend should lead to an increasingly important source of new medicines to improve human health.

Additional Information

© 2019 Elsevier Inc. Available online 21 June 2019. The NIH-NIGMS (R01GM080269) and Caltech are thanked for support of our research program. A.W.S. thanks the NIH-NIGMS for a predoctoral fellowship (Ruth L. Kirschstein Institutional National Research Service Award F30GM120836) and a UCLA-Caltech Medical Scientist Training Program Fellowship (T32GM008042). S.L. acknowledges the Deutsche Forschungsgemeinschaft (DFG) for a postdoctoral fellowship (LA 4220/1-1).

Additional details

August 22, 2023
October 20, 2023