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Published October 26, 2004 | Published
Book Section - Chapter Open

In vivo tomographic imaging based on bioluminescence


The most important task for bioluminescence imaging is to identify the emission source from the captured bioluminescent signal on the surface of a small tested animal. Quantitative information on the source location, geometry and intensity serves for in-vivo monitoring of infectious diseases, tumor growth, metastases in the small animal. In this paper, we present a point-spread function-based method for reconstructing the internal bioluminescent source from the surface light output flux signal. The method is evaluated for sensing the internal emission sources in nylon phantoms and within a live mouse. The surface bioluminescent signal is taken with a highly sensitive CCD camera. The results show the feasibility and efficiency of the proposed point-spread function-based method.

Additional Information

© 2004 Society of Photo-optical Instrumentation Engineers (SPIE). This work is partially supported by NIH/NIBIB grants (EB001685).

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