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Published March 1, 2003 | public
Journal Article

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models


Motivation: Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively. Results: We summarize the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks. SBML is a software-independent language for describing models common to research in many areas of computational biology, including cell signaling pathways, metabolic pathways, gene regulation, and others.

Additional Information

© 2003 Oxford University Press. Received on May 17, 2002; revised on October 15, 2002; accepted on October 25, 2002. This work has been supported by: the Japan Science and Technology Corporation's ERATO Kitano Symbiotic Systems Project; an International Joint Research Grant from the NEDO/Japanese Ministry of Economy, Trade and Industry; and the Rice Genome and Simulation Project from the Japanese Ministry of Agriculture.

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