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Published November 22, 2023 | Published
Journal Article Open

Genome Mining from Agriculturally Relevant Fungi Led to a D-Glucose Esterified Polyketide with a Terpene-like Core Structure


Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin, which has a terpene-like, trans-fused 5,7-bicyclic core that is proposed to derive from a (4 + 3) cycloaddition. The core is esterified with d-glucose, which derives from the glycosidic cleavage of a trehalose ester precursor. This glycomodification strategy is different from the commonly observed glycosylation of natural products.

Copyright and License

© 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.


This work was supported by NIFA 2021-67013-34259 (Y.T.) and the HHMI EPI Initiative (Y.T. and H.N.). Chemical characterization studies were supported by shared instrumentation grants from the NSF (CHE-1048804) and the NIH NCRR (S10RR025631). C.Y. was supported by NIGMS predoctoral fellowship 5T32GM136614-04. K.N.H. acknowledges the Saul Winstein Chair in Organic Chemistry for funding. Calculations were performed at Expanse at SDSC through Allocation CHE040014 from the Advanced Cyberinfrastructure Coordination Ecosystem: Services & Support (ACCESS) Program, which is supported by National Science Foundation Grants 2138259, 2138286, 2138307, 2137603, and 2138296.

Conflict of Interest

The authors declare no competing financial interest.

Additional Information

CCDC 2295175 contains the supplementary crystallographic data for this paper.



Additional details

November 30, 2023
November 30, 2023