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Published March 1, 1981 | public
Journal Article Open

Recovery of protein synthesis after heat shock: Prior heat treatment affects the ability of cells to translate mRNA


A mild heat shock at 35 degrees C, which induces heat shock gene expression, greatly enhances survival and the recovery of protein synthesis in Drosophila cells after a higher temperature heat shock. The 35 degrees C treatment is also effective in preventing heat-induced developmental defects in pupae. We show here that the major larval mRNAs are present in approximately normal (25 degrees C) concentrations after a 40.1 degrees C heat shock whether or not the animals receive a pretreatment. This indicates that the pretreatment affects translation directly rather than messenger concentration. We also observe selective translation of heat shock messages and some 25 degrees C messages during recovery from heat shock.

Additional Information

© 1981 by the National Academy of Sciences. Communicated by Norman Davidson, November 24, 1980. This work was supported by U.S. Public Health Service Grants GM 25966A-01 and AG 01931A-01.


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