Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain

Abstract

Significance Our the brain actively responds to changes in the environment by remodeling neural circuits. One important aspect of neuroplasticity is adult neurogenesis, which involves the generation, survival, and incorporation of new neurons into existing circuits and is unique to two discrete areas of the mammalian brain. The hippocampus, critical for learning and memory, is one such area that exhibits ongoing neurogenesis throughout an individual's lifetime. Although recent studies have confirmed that hippocampal behaviors regulate neurogenesis, the mechanistic pathways governing that regulatory activity remain poorly understood. In this work, we found that hippocampal behaviors increase inhibitory circuit activity through a metabolic pathway, and established a computational model to quantitively model the relationship between circuit activity and control of hippocampal neurogenesis.

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