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Published July 15, 1983 | public
Journal Article

Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor


The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth.

Additional Information

© 1983 American Association for the Advancement of Science. 3 June 1983; Revised 12 June 1983. We thank T. Hunkapiller for preparation of Fig. 1, and the American Red Cross Blood Services, Northeast Section, for the supply of clinically outdated human platelets. Supported in part by NIH research grants RR00757 (R.F.D.) and CA30101 (H.N.A.) and by grants from the Council for Tobacco Research, USA, Inc. (H.N.A.) and the Weingart Foundation (L.E.H.).

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