Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 2017 | Supplemental Material + Published
Journal Article Open

Recent Advancements in Stereoselective Olefin Metathesis Using Ruthenium Catalysts


Olefin metathesis is a prevailing method for the construction of organic molecules. Recent advancements in olefin metathesis have focused on stereoselective transformations. Ruthenium olefin metathesis catalysts have had a particularly pronounced impact in the area of stereoselective olefin metathesis. The development of three categories of Z-selective olefin metathesis catalysts has made Z-olefins easily accessible to both laboratory and industrial chemists. Further design enhancements to asymmetric olefin metathesis catalysts have streamlined the construction of complex molecules. The understanding gained in these areas has extended to the employment of ruthenium catalysts to stereoretentive olefin metathesis, the first example of a kinetically E-selective process. These advancements, as well as synthetic applications of the newly developed catalysts, are discussed.

Additional Information

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). R.H.G. acknowledges the National Institutes of Health for support. T.P.M. acknowledges the Arnold and Mabel Beckman Foundation for support. William J. Wolf and Christopher B. Marotta are thanked for helpful discussions. Author Contributions: R.H.G. conceived the idea for this manuscript. T.P.M. narrowed the topic for this manuscript and contributed to data acquisition and drafting all sections of this manuscript. A.M.J. contributed to data acquisition and drafting portions of the Z-Selective, Stereoretentive, and Synthetic Applications sections. All authors contributed to editing and revising the manuscript. The authors declare no conflict of interest.

Attached Files

Published - catalysts-07-00087-v2.pdf

Supplemental Material - catalysts-07-00087-s001.pdf


Files (14.2 MB)
Name Size Download all
14.2 MB Preview Download
37.7 kB Preview Download

Additional details

August 22, 2023
October 25, 2023