Published June 6, 2016
| Version Published
Journal Article
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How inhibitory cues can both constrain and promote cell migration
Abstract
Collective cell migration is a common feature in both embryogenesis and metastasis. By coupling studies of neural crest migration in vivo and in vitro with mathematical modeling, Szabó et al. (2016, J. Cell Biol., http://dx.doi.org/10.1083/jcb.201602083) demonstrate that the proteoglycan versican forms a physical boundary that constrains neural crest cells to discrete streams, in turn facilitating their migration.
Additional Information
© 2016 Bronner. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unpor ted license as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Submitted: 19 May 2016; Accepted: 20 May 2016. I thank Paige O'Connell for drawing Fig. 1. Work in the Bronner laboratory is supported by National Institutes of Health grants DE024157 and HD037105. The author declares no conflicting financial interests.Attached Files
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Additional details
Identifiers
- PMCID
- PMC4896061
- Eprint ID
- 67845
- Resolver ID
- CaltechAUTHORS:20160610-133948679
Funding
- NIH
- DE024157
- NIH
- HD037105
Dates
- Created
-
2016-06-10Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field