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Published July 2012 | Published
Journal Article Open

Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography


With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.

Additional Information

© 2012 SPIE. Paper 12179 received Mar. 15, 2012; revised manuscript received Jun. 4, 2012; accepted for publication Jun. 6, 2012; published online Jul. 6, 2012. The authors appreciate Ms. Seema Dahlheimer's and Jim Ballard's close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, R01 CA157277, and R01 CA159959. L. Wang has financial interests in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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