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Published March 2019 | Accepted Version
Journal Article Open

The Neuropsychological Syndrome of Agenesis of the Corpus Callosum


Background: Agenesis of the corpus callosum (AgCC) involves congenital absence of all or part of the corpus callosum. Because the disorder can only be firmly diagnosed via neuroradiology, it has a short research history, and only recently has the cognitive syndrome become clear. Purpose: Our purpose is to review the primary deficits in AgCC that constitute the core syndrome. Conclusions: The cores syndrome includes: (1) reduced interhemispheric transfer of sensory-motor information; (2) reduced cognitive processing speed; and (3) deficits in complex reasoning and novel problem-solving. These domains do not appear to reflect different neuroanatomical abnormalities, but rather different domains of expression of reduced interhemispheric communication from callosal absence. Implications: These core deficits are expressed across various domains of cognitive, behavioral, and social functioning. The impact of these deficits varies across development and may be moderated by individual factors such as co-occurrence of other neurodevelopmental conditions, general intellectual capacity, and environmental support.

Additional Information

© The International Neuropsychological Society 2019. Published online: 29 January 2019. RECEIVED March 28, 2018; FINAL REVISION September 13, 2018; ACCEPTED November 5, 2018. The authors of this paper declare that they have no conflicts of interest with respect to the writing of this paper or the information contained. The writing of this paper was also not supported by grant funding.

Attached Files

Accepted Version - Brown_Paul.ACC_Syndrome.Revision.pdf

Accepted Version - nihms-1678983.pdf


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