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Published December 2017 | public
Journal Article

Polθ helicase: drive or reverse


The helicase intrinsic to DNA polymerase θ (Polθ), the versatile mediator of microhomology-based repair of DNA double-strand breaks and stalled replication forks, is now revealed to be a member of an elite group of proteins known as annealing helicases. This small family of enzymes remodels DNA intermediates in multiple repair processes that are crucial to preserving genome stability and warding off cancer and aging.

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© 2017 Macmillan Publishers Limited, part of Springer Nature. Published online07 December 2017. Competing interests: The authors declare no competing financial interests.

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