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Published August 29, 1986 | public
Journal Article

Long-range electron transfer in heme proteins


Kinetic experiments have conclusively shown that electron transfer can take place over large distances (greater than 10 angstroms) through protein interiors. Current research focuses on the elucidation of the factors that determine the rates of long-range electron-transfer reactions in modified proteins and protein complexes. Factors receiving experimental and theoretical attention include the donor-acceptor distance, changes in geometry of the donor and acceptor upon electron transfer, and the thermodynamic driving force. Recent experimental work on heme proteins indicates that the electron-transfer rate falls off exponentially with donor-acceptor distance at long range. The rate is greatly enhanced in proteins in which the structural changes accompanying electron transfer are very small.

Additional Information

© 1986 American Association for the Advancement of Science. Supported by grants from the National Science Foundation (CHE85-09637 and CHE85-18793). S.L.M. is an AT&T Bell Laboratories predoctoral fellow (1983 to the present). R.J.C. held a postdoctoral fellowship from the Natural Sciences and Engineering Research Council of Canada during 1982-84. H.B.G. was Visiting Miller Research Professor at the Department of Chemistry, University of California, Berkeley, when the manuscript was completed. We thank the following colleagues for helpful discussion: K. M. Yocom, J. R. Winkler, E. Bordignon, D. G. Nocera, J. B. Shelton, J. R. Shelton, W. A. Schroeder, J. N. Onuchic, G. Worosila, S. S. Isied, B. M. Hoffman, G. L. McLendon, R. A. Scott, A. G. Mauk, M. R. Mauk, N. S. Hush, R. A. Marcus, N. Sutin, J. J. Hopfield, D. N. Beratan, G. L. Closs, M. Smith, G. Pielak, B. D. Olafson, J. L. Campbell, J. H. Richards, W. A. Goddard III, I. Pecht, A. W. Axup, A. A. da Gama, M. Albin, J. H. Dawson, H. Taube, J. R. Miller, B. G. Malmstrom, W. R. Scheidt, and S. Larsson. Contribution 7334 from the Arthur Amos Noyes Laboratory.

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