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Published May 1, 1965 | public
Journal Article Open

The twisted circular form of polyoma viral DNA


The major part of the DNA from polyoma virus has been shown to consist of circular base-paired duplex molecules without chain ends.(1-3) The intertwined circular form accounts for the ease of renaturation(4) of this DNA and the failure of the strands to separate in strand-separating solvents.(1-3)

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© 1965 by the National Academy of Sciences. Communicated by Norman Davidson, March 30, 1965. This work was reported in part at the 9th Annual Meeting of the Biophysical Society, February 24, 1965. Contribution 3227 of Gates and Crellin Laboratories of Chemistry. It is a pleasure to thank I. R. Lehman for the generous gift of the E. coli enzymes, R.L. Sinsheimer, J. Petruska, and M. Fried for helpful discussions, R. Dulbecco for allowing us to quote his unpublished results, and T. Benjamin, L. Wenzel, and A. Drew for advice and assistance in the culture of the virus and the assay of the DNA. This work was supported in part by grants HE 03394 and CA 08014 from the U.S. Public Health Service.


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