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Published October 1, 1999 | public
Journal Article

Lineages and transcription factors in the specification of vertebrate primary sensory neurons


Recent advances have indentified some of the key transcriptional regulators of mammalian genes, the neurogenins. Neurogenins 1 and 2 appear to control distinct sublineages for different classes of sensory neurons, including a 'pioneer' lineage for proprioceptors specified early in neural crest migration. Neurogenins act via a cascade of downstream transcriptional regulators, some of which have been identified.

Additional Information

© 1999 Elsevier Science Ltd. Available online 28 December 1999. Tire author thanks members of his laboratory, TM Jessell and E Frank for insightful discussions. Portions of the work from the author's laboratory were supported by grants from the March of Dimes and an NIMH Silvio Conic Center grant (Henry bester, PI). DJ Anderson is an Investigator of the Howard Hughes Medical Institute.

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October 20, 2023