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Published 2010 | Published
Book Section - Chapter Open

Parylene membrane slot filter for the capture, analysis and culture of viable circulating tumor cells


This paper presents a method of capturing viable circulating tumor cells (CTC) from human whole blood using constant-pressure-driven filtration through a specially designed parylene-C membrane "slot" filter. More than 90% viable cancer cells could be recovered from whole blood using the slot filter, with minimal non-cancer blood cells left on the filter. The feasibility of the telomerase activity measurement of a single cancer cell taken from the filter after capture was proven. The on-filter and off-filter cultures of the captured cancer cells were also demonstrated.

Additional Information

© 2010 IEEE. The funding of this project is provided by NIH/NCI 1R01CA141077-01, and The Hope Foundation SWOG0421.

Attached Files

Published - Lu2010p10655Mems_2008_21St_Ieee_International_Conference_On_Micro_Electro_Mechanical_Systems_Technical_Digest.pdf



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August 19, 2023
January 12, 2024